The important intermediate, heptapeptide, was synthesized by the stepwise elongation method using carbobenzoxy amino acid p-nitrophenyl esters by solution technique. Azide synthesis was used to get the nonapeptide. 先用逐步增长方式采用对硝基苯酚酯法缩合得到重要中间体七肽片段,再用叠氮法缩合得到保护九肽。
In this dissertation, using dimeric fatty acid, sodium azide, triphenylphosphine and N-chloro succinimide as raw material, DDI was synthesized via staudinger rearrangement reaction. 本文以二聚脂肪酸、叠氮化钠、三苯基膦及N-氯代丁二酰亚胺为原料,通过Staudinger重排制备了三十四碳二聚脂肪酸二异氰酸酯(DDI)。